The third-ranked Notre Dame Fighting Irish look to stay perfect on the year when they take on the Pittsburgh Panthers in a key ACC matchup on Saturday afternoon. The Fighting Irish (4-0) are coming off a 12-7 win over Louisville last Saturday. The Panthers (3-3), meanwhile, dropped a 31-19 decision at Miami last week without starting quarterback Kenny Pickett (ankle). Kickoff from Heinz Field in Pittsburgh is set for 3:30 p.m. ET.
Notre Dame leads the all-time series 49-21-1, including a 27-11-1 edge in games played at Pittsburgh. The Fighting Irish are 10-point favorites in the latest Notre Dame vs. Pittsburgh odds from William Hill, while the over-under for total points scored is set at 42.5. Before making any Pittsburgh vs. Notre Dame picks, check out the college football predictions from the SportsLine Projection Model.
The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past