Vacunacionadultos

Ascentage Pharma Enters into an Agreement with University of Michigan to obtain an exclusive license for a MDM2 Degrader using PROTAC Technology

SUZHOU, China and ROCKVILLE, Md., Nov. 29, 2020 /PRNewswire/ — Ascentage Pharma (6855.HK), a globally focused, clinical-stage biotechnology company engaged in developing novel therapies for cancers, chronic hepatitis B (CHB), and age-related diseases, today announced it has entered into an agreement with the University of Michigan, through which the company may obtain the exclusive global rights to a MDM2 protein degrader developed using the Proteolysis-Targeting Chimeras (PROTACs) technology. The drug candidate is currently entering IND-enabling studies.

MDM2 is a key regulator of the tumor suppressor p53 and one of the most potent inhibitors of apoptosis discovered thus far. It has high expression in tumors and plays a key role in the occurrence and development of tumors. Binding to the MDM2 protein with high affinity, MDM2 inhibitor blocks the MDM2-p53 interactions and restore the tumor-suppressing activity of p53.1 Meanwhile, these MDM2 inhibitors present some challenges, including dose-limiting hematological

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Fla. education chief moves to strip license from principal in Holocaust furor

Florida’s education commissioner inserted himself into the roiling controversy over the reinstatement of a Palm Beach County principal who declined to call the Holocaust a fact, directing his administration to strip the principal’s educator certificate.



a man standing in front of a table: Fired Spanish River High Principal William Latson listens Tuesday as Dr. Donald E. Fennoy II, superintendent of the Palm Beach County School District, testifies during an administrative court hearing in which Latson is try to get his job back.


© ALLEN EYESTONE/palmbeachpost.com
Fired Spanish River High Principal William Latson listens Tuesday as Dr. Donald E. Fennoy II, superintendent of the Palm Beach County School District, testifies during an administrative court hearing in which Latson is try to get his job back.

Education Commissioner Richard Corcoran said Friday that former Spanish River High School Principal William Latson “took advantage of his position of trust” and that state officials had a duty to remove the certificate that authorizes him to educate public school students.

Latson, who sparked international controversy last year by telling a parent he couldn’t say the Holocaust was a historical fact, was reinstated last week by the county school board, prompting a new

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Rain International LLC Granted Exclusive License of Seed Based Patent Application by University of Maryland

OREM, Utah – October 16, 2020 – ( Newswire.com )

“Academic industry agreements like this one between the University of Maryland and Rain International are a great example of transferring new technologies from the laboratory bench to the market, bringing these discoveries to consumers,” said Dr. Kenneth Porter, Director, UM Ventures, College Park.

“This opportunity we have, to leverage and utilize these new technologies and discoveries from the University of Maryland, is something that is unique to our company,” said Byron Belka, the CEO and Founder of Rain International. “It’s going to improve the way we do things in an enormous way, which, consequently, will improve the lives and lifestyles of others in the process.”

Dr. Yu’s work is unique because it adds value to seed flour which is normally a waste product. She has investigated the nutritional value of seed flour in gut microbiota modulation, reducing oxidative stress and

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