The Kansas State Wildcats and the Iowa State Cyclones are set to square off in a Big 12 battle at 4 p.m. ET on Saturday at Jack Trice Stadium. Iowa State is 5-2 overall and 3-1 at home, while the Wildcats are 4-3 overall and 2-1 on the road. This is the 104th all-time meeting between these two programs and the Cyclones are clinging to a 50-49-3 edge in the series despite the fact that Kansas State has won 11 of 12 head-to-head matchups.
Kansas State is 5-2 against the spread this season, while Iowa State is 3-4 against the number. The Cyclones are favored by 10.5-points in the latest Iowa State vs. Kansas State odds from William Hill Sportsbook, and the over-under is set at 47.5. Before entering any Kansas State vs. Iowa State picks, you’ll want to see the college football predictions from the model at SportsLine.